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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab)   

Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab)

Recombinant Antibody

     
  • 0 - Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab) APR10667
    Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
  • 0 - Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab) APR10667
    The purity of Anti-IL-1RL1 / ST2 / IL-33R Reference Antibody (astegolimab)is more than 100% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession Q01638
Reactivity Human, Mouse
Clonality Monoclonal
Isotype IgG2SA
Calculated MW 63358 Da
Additional Information
Target/Specificity IL-1RL1 / ST2 / IL-33R
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name IL1RL1
Synonyms DER4, ST2, T1
Function Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016). Upon tissue injury, induces UCP2- dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3- dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
Cellular Location [Isoform C]: Cell membrane. Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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