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Anti-TMEFF1 / Tomoregulin-1 Reference Antibody (Bluefin patent anti-TMEFF1)

Recombinant Antibody

Anti-TMEFF1 / Tomoregulin-1 Reference Antibody (Bluefin patent anti-TMEFF1) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TMEFF1 / Tomoregulin-1 Reference Antibody (Bluefin patent anti-TMEFF1) is more than 95%, determined by SEC-HPLC.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q8IYR6
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	40934 Da

Additional Information
Target/Specificity	TMEFF1 / Tomoregulin-1
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	TEFF1
Function	Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823, PubMed:39048830). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (PubMed:39048823). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (PubMed:39048823, PubMed:39048830). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (PubMed:39048823). May be a tumor suppressor in brain cancers (PubMed:12743596).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle (PubMed:12743596). Down- regulated in brain tumors as compared to control brain tissues (PubMed:12743596).