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Anti-TIM-1 / HAVCR1 Reference Antibody (CRX-014)

Anti-TIM-1 / HAVCR1 Reference Antibody (CRX-014) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TIM-1 / HAVCR1 Reference Antibody (CRX-014) is 95.91%, determined by SEC-HPLC.
Immobilized Human TIM-1 / HAVCR1,His Tag at 2 µg/mL can bind CRX-014, EC50= 0.02674 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q96D42
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG2SA
Calculated MW	39250 Da

Additional Information
Target/Specificity	TIM-1 / HAVCR1
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	HAVCR1
Synonyms	KIM1, TIM1, TIMD1
Function	Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (PubMed:18082433, PubMed:18414680). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (PubMed:18082433). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:17471468, PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (PubMed:18414680). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (PubMed:18414680). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Acts as a regulator of T-cell proliferation (By similarity). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity).
Cellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome
Tissue Location	Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.