> 首页 > 产品 > 一抗 > 其他 > Anti-CCR8 / CD198 Reference Antibody (BMS-986340)

Anti-CCR8 / CD198 Reference Antibody (BMS-986340)

Anti-CCR8 / CD198 Reference Antibody (BMS-986340) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CCR8 / CD198 Reference Antibody (BMS-986340) is 100%, determined by SEC-HPLC.
Immobilized Human CCR8-VLP at 16 µg/mL can bind BMS-986340, EC50= 10.44 µg/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P51685
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-REMK
Calculated MW	40844 Da

Additional Information
Target/Specificity	CCR8 / CD198 / CKRL1 / CMKBR8 / CMKBRL2
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CCR8
Synonyms	CKRL1, CMKBR8, CMKBRL2
Function	G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed:23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed:35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity).
Cellular Location	Cell membrane; Multi-pass membrane protein
Tissue Location	Expressed in unstimulated CD4(+) and CD8(+) T-cells and polymorphonuclear cells.