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Anti-VEGI Reference Antibody (Tulisokibart)

Anti-VEGI Reference Antibody (Tulisokibart) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-VEGI Reference Antibody (Tulisokibart) is 96.4%, determined by SEC-HPLC.
Immobilized TL1A/VEGI/ TNFSF15-N-His at 2 µg/mL can bind Tulisokibart, EC50= 0.01821 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O95150
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-LALA-P329A
Calculated MW	28087 Da

Additional Information
Target/Specificity	TNFSF15 / VEGI
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	TNFSF15
Synonyms	TL1, TL1A {ECO:0000303\|PubMed:21300286},
Function	Cytokine that signals through TNFRSF25 receptor (PubMed:11911831). Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells (PubMed:10597252, PubMed:11911831). Inhibits vascular endothelial growth and angiogenesis (in vitro) (PubMed:11923219, PubMed:9872942). Binds to the decoy receptor TNFRSF6B, blocking the activation normally triggered by TNFSF15 and leading to decreased T- cell activation and reduced inflammation (PubMed:21300286).
Cellular Location	Membrane; Single-pass type II membrane protein
Tissue Location	Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon