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Anti-IL-4Ra / CD124 Reference Antibody (Stapokibart)

Anti-IL-4Ra / CD124 Reference Antibody (Stapokibart) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-IL-4Ra / CD124 Reference Antibody (Stapokibart) is 99.37%, determined by SEC-HPLC.
Immobilized human I4R ECD (26-232)-Nhis at 2 µg/mL can bind Stapokibart, EC50= 0.02815 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P24394
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP
Calculated MW	89658 Da

Additional Information
Target/Specificity	IL-4Ra / CD124
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	IL4R
Synonyms	IL4RA
Function	Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Isoform 1 and isoform 2 are highly expressed in activated T-cells

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol