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Anti-TNFSF5 / CD40L / CD154 Reference Antibody (Tegoprubart)

Anti-TNFSF5 / CD40L / CD154 Reference Antibody (Tegoprubart) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TNFSF5 / CD40L / CD154 Reference Antibody (Tegoprubart) is 99.2%, determined by SEC-HPLC.
Immobilized SYMX14-Hu CD40L(116-261)-His at 2 µg/mL can bind Tegoprubart, EC50= 0.04316 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P29965
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-CS-CS-CS-PS
Calculated MW	29274 Da

Additional Information
Target/Specificity	TNFSF5 / CD40L / CD154
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CD40LG
Synonyms	CD40L, TNFSF5, TRAP
Function	Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
Cellular Location	Cell membrane; Single-pass type II membrane protein. Cell surface
Tissue Location	Specifically expressed on activated CD4+ T- lymphocytes