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Anti-IL-18R Beta Reference Antibody (Jing Medicine patent anti-IL-18R Beta)

Anti-IL-18R Beta Reference Antibody (Jing Medicine patent anti-IL-18R Beta) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-IL-18R Beta Reference Antibody (Jing Medicine patent anti-IL-18R Beta) is 98.02%, determined by SEC-HPLC.
Hu IL-18Rα-Hu IL-18Rβ-HEK293-A8 cell line were stained with Jing Medicine patent anti-IL-18R Beta and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 1.023 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O95256
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP-Opti
Calculated MW	68310 Da

Additional Information
Target/Specificity	IL-18RB
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	IL18RAP (HGNC:5989)
Synonyms	IL1R7
Function	Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:14528293, PubMed:25500532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836) Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).