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Anti-PD-L2 Reference Antibody (Merck patent anti-PD-L2)

Anti-PD-L2 Reference Antibody (Merck patent anti-PD-L2) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-PD-L2 Reference Antibody (Merck patent anti-PD-L2) is 98.6%, determined by SEC-HPLC.
Immobilized hu-PD-L2-ECD-His at 2 µg/mL can bind Merck patent anti-PD-L2, EC50= 0.01093 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q9BQ51
Reactivity	Human
Clonality	Monoclonal
Isotype	mIgG1
Calculated MW	30957 Da

Additional Information
Target/Specificity	PD-L2 / CD273
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	PDCD1LG2
Synonyms	B7DC, CD273, PDCD1L2, PDL2
Function	Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527).
Cellular Location	[Isoform 3]: Secreted [Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location	Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus