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Anti-ENTPD2 Reference Antibody (Novartis patent anti-ENTPD2)

Anti-ENTPD2 Reference Antibody (Novartis patent anti-ENTPD2) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ENTPD2 Reference Antibody (Novartis patent anti-ENTPD2) is 97.11%, determined by SEC-HPLC.
Immobilized huNTPDase/ENTPD2-his at 8 µg/mL can bind Novartis patent anti-ENTPD2, EC50= 0.01037 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q9Y5L3
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-REM
Calculated MW	53665 Da

Additional Information
Target/Specificity	ENTPD2
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ENTPD2 (HGNC:3364)
Function	Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). All nucleoside 5'- diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity).
Cellular Location	[Isoform Long]: Cell membrane; Multi-pass membrane protein [Isoform gamma]: Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location	Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas (PubMed:9271669). No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes (PubMed:9271669)