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Anti-HHLA2 Reference Antibody (HBM1020)

Anti-HHLA2 Reference Antibody (HBM1020) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-HHLA2 Reference Antibody (HBM1020) is 99.57%, determined by SEC-HPLC.
Immobilized huHHLA2-ECD-His at 2 µg/mL can bind HBM1020, EC50= 0.01175 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q9UM44
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-LALA-EM
Calculated MW	46850 Da

Additional Information
Target/Specificity	HHLA2
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	HHLA2
Function	Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Cellular Location	Membrane; Single-pass type I membrane protein
Tissue Location	Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol