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Anti-DR3 Reference Antibody (PTX-35)

Anti-DR3 Reference Antibody (PTX-35) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-DR3 Reference Antibody (PTX-35) is 97.74%, determined by SEC-HPLC.
Immobilized Human-DR3-his at 2 µg/mL can bind PTX-35, EC50= 0.2840 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q93038
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	45385 Da

Additional Information
Target/Specificity	DR3
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	TNFRSF25
Synonyms	APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Function	Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 9]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted. [Isoform 5]: Secreted. [Isoform 7]: Secreted. [Isoform 10]: Secreted.
Tissue Location	Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate

Research Areas