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Anti-CXCR2 / IL-8Rb / CD182 Reference Antibody (Shanghai Tech.U. patent anti-CXCR2)

Anti-CXCR2 / IL-8Rb / CD182 Reference Antibody (Shanghai Tech.U. patent anti-CXCR2) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CXCR2 / IL-8Rb / CD182 Reference Antibody (Shanghai Tech.U. patent anti-CXCR2) is 98.6%, determined by SEC-HPLC.
Immobilized PHE253 Human CXCR2 / IL-8Rb / CD182, His Tag at 2 µg/mL can bind ShanghaiTech.U.patentanti-CXCR2, EC50= 0.01359 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P25025
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	40759 Da

Additional Information
Target/Specificity	CXCR2 / IL-8Rb / CD182
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CXCR2
Synonyms	IL8RB
Function	Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G- protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (PubMed:1891716). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site.
Cellular Location	Cell membrane; Multi-pass membrane protein.

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol