> 首页 > 产品 > 一抗 > 其他 > Anti-MSR1 Reference Antibody (Regeneron patent anti-MSR1)

Anti-MSR1 Reference Antibody (Regeneron patent anti-MSR1)

Anti-MSR1 Reference Antibody (Regeneron patent anti-MSR1) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-MSR1 Reference Antibody (Regeneron patent anti-MSR1) is 98.58%, determined by SEC-HPLC.
PLVX-puro-MSR1-FL cell line were stained with Regeneron patent anti-MSR1 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 1.273 nM.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P21757
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	49762 Da

Additional Information
Target/Specificity	MSR1
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	MSR1
Synonyms	SCARA1
Function	Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis (PubMed:2251254, PubMed:34252459). Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense (PubMed:10722588). Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling (PubMed:29057947, PubMed:40980882).
Cellular Location	Cell membrane; Single-pass type II membrane protein
Tissue Location	Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.