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Anti-Thrombin Reference Antibody (U.Cambridge patent anti-Thrombin)

Anti-Thrombin Reference Antibody (U.Cambridge patent anti-Thrombin) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-Thrombin Reference Antibody (U.Cambridge patent anti-Thrombin) is 98.4%, determined by SEC-HPLC.
Immobilized hu-Thrombin-his at 2 µg/mL can bind U.Cambridge patent anti-Thrombin, EC50= 0.4002 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P00734
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP-opti
Calculated MW	70037 Da

Additional Information
Target/Specificity	Thrombin
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	F2
Function	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro- inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208).
Cellular Location	Secreted, extracellular space.
Tissue Location	Expressed by the liver and secreted in plasma.