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Anti-GFRA4 Reference Antibody (U.Penn. patent anti-GFRA4)

Anti-GFRA4 Reference Antibody (U.Penn. patent anti-GFRA4) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-GFRA4 Reference Antibody (U.Penn. patent anti-GFRA4) is 98.3%, determined by SEC-HPLC.
Immobilized hu-GFRA4-his at 2 µg/mL can bind U.Penn. patent anti-GFRA4, EC50= 2.554 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P56159
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	51456 Da

Additional Information
Target/Specificity	GFRA4
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	GFRA1
Synonyms	GDNFRA, RETL1, TRNR1
Function	Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10829012, PubMed:31535977). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250\|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250\|UniProtKB:Q62997}. Endosome {ECO:0000250\|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250\|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies {ECO:0000250\|UniProtKB:Q62997}

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol