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Anti-BMPR1B Reference Antibody (Abbvie StemCentrx patent anti-BMPR1B)

Anti-BMPR1B Reference Antibody (Abbvie StemCentrx patent anti-BMPR1B) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-BMPR1B Reference Antibody (Abbvie StemCentrx patent anti-BMPR1B) is 100%, determined by SEC-HPLC.
PLVX-puro-BMPR1B-FL cell line were stained with Abbvie StemCentrx patent anti-BMPR1B and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.4332 nM.

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实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O00238
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	56930 Da

Additional Information
Target/Specificity	BMPR1B
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	BMPR1B
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Cellular Location	Cell membrane; Single-pass type I membrane protein

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol