> 首页 > 产品 > 一抗 > 其他 > Anti-CD180 Reference Antibody (Champions Oncology patent anti-CD180)

Anti-CD180 Reference Antibody (Champions Oncology patent anti-CD180)

Anti-CD180 Reference Antibody (Champions Oncology patent anti-CD180) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CD180 Reference Antibody (Champions Oncology patent anti-CD180) is 99.7%, determined by SEC-HPLC.
PLVX-puro-CD180-FL cell line were stained with Champions Oncology patent anti-CD180 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 6.027 nM.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q99467
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-REM-noK
Calculated MW	74179 Da

Additional Information
Target/Specificity	CD180
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CD180
Synonyms	LY64, RP105
Function	Pattern recognition receptor predominantly expressed on B- cells, dendritic cells, and certain monocytes/macrophages, structurally resembling Toll-like receptors (TLRs) that plays a role in modulating immune responses (PubMed:15852007). While ressembling a TLR, lacks the intracellular TIR (Toll/IL-1R) signaling domain and thus does not directly transduce signals. Instead, modulates immune responses, often in conjunction with other TLRs. For example, in cooperation with MD- 1/LY86, interacts directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligand (PubMed:15852007).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells