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Anti-Kremen2 Reference Antibody (Abbvie Stemcentrx patent anti-Kremen2)

Anti-Kremen2 Reference Antibody (Abbvie Stemcentrx patent anti-Kremen2) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-Kremen2 Reference Antibody (Abbvie Stemcentrx patent anti-Kremen2) is 97.45%, determined by SEC-HPLC.
PLVX-puro-Kremen2-FL cell line were stained with Abbvie Stemcentrx patent anti-Kremen2 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.768 nM.

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实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q8NCW0
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-CS-N297A-noK-Opti
Calculated MW	48849 Da

Additional Information
Target/Specificity	Kremen2
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	KREMEN2
Synonyms	KRM2
Function	Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.
Cellular Location	Membrane; Single-pass type I membrane protein

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol