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Anti-CCR1 / CD191 Reference Antibody (KHK patent anti-CCR1)

Anti-CCR1 / CD191 Reference Antibody (KHK patent anti-CCR1) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CCR1 / CD191 Reference Antibody (KHK patent anti-CCR1) is 99.27%, determined by SEC-HPLC.
PLVX-puro-hu CCR1-E-coil cell line were stained with KHK patent anti-CCR1 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.539 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P32246
Reactivity	Human
Clonality	Monoclonal
Isotype	lgG4PE
Calculated MW	41173 Da

Additional Information
Target/Specificity	CCR1 / CD191
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CCR1
Synonyms	CMKBR1, CMKR1, SCYAR1
Function	Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581, PubMed:38417634). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity).
Cellular Location	Cell membrane; Multi-pass membrane protein
Tissue Location	Widely expressed in different hematopoietic cells.