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Anti-IGSF1 Reference Antibody (WM-A1-3389)

Anti-IGSF1 Reference Antibody (WM-A1-3389) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-IGSF1 Reference Antibody (WM-A1-3389) is 99.33%, determined by SEC-HPLC.
PLVX-puro-IGSF1(560aa-1336aa) cell line were stained with WM-A1-3389 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 1.087 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q8N6C5
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-EM
Calculated MW	148936 Da

Additional Information
Target/Specificity	IGSF1
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	IGSF1
Synonyms	IGDC1, KIAA0364, PGSF2
Function	Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription.
Cellular Location	[Isoform 1]: Membrane; Multi-pass membrane protein [Isoform 3]: Secreted.
Tissue Location	Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland.

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol