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Anti-Complement C5 Reference Antibody (Pexelizumab)

Anti-Complement C5 Reference Antibody (Pexelizumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-Complement C5 Reference Antibody (Pexelizumab) is 99.7%, determined by SEC-HPLC.
Immobilized Human Complement C5 Protein, It’s target at 3 µg/mL can bind Pexelizumab（ScFv-noTag）, EC50= 1.235 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P01031
Reactivity	Human
Clonality	Monoclonal
Isotype	ScFv-C-6His
Calculated MW	188305 Da

Additional Information
Target/Specificity	Complement C5
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	C5 {ECO:0000303\|PubMed:1984448, ECO:0000312\|HGNC:HGNC:1331}
Function	Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:6554279). Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279).
Cellular Location	Secreted. [C5a anaphylatoxin]: Secreted