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Anti-STEAP2 Reference Antibody (AstraZeneca patent anti-STEAP2)

Anti-STEAP2 Reference Antibody (AstraZeneca patent anti-STEAP2) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-STEAP2 Reference Antibody (AstraZeneca patent anti-STEAP2) is 98.4%, determined by SEC-HPLC.
PLVX-puro-STEAP2-FL cell line were stained with AstraZeneca patent anti-STEAP2 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 24.83 nM.

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实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q8NFT2
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-REM-LFLE-PS
Calculated MW	56056 Da

Additional Information
Target/Specificity	STEAP2
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	STEAP2
Synonyms	PCANAP1, STAMP1
Function	Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
Cellular Location	Endosome membrane {ECO:0000250\|UniProtKB:Q8BWB6}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location	Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol