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Anti-GFRA4 Reference Antibody (Novartis patent anti-GFRA4 CAR)

Anti-GFRA4 Reference Antibody (Novartis patent anti-GFRA4 CAR) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-GFRA4 Reference Antibody (Novartis patent anti-GFRA4 CAR) is 98.85%, determined by SEC-HPLC.
Immobilized hu-GFRα4b-Fc, It’s target at 2 µg/mL can bind Novartis patent anti-GFRA4 CAR, EC50= 0.7077 µg/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q9GZZ7
Reactivity	Human
Clonality	Monoclonal
Isotype	ScFv-C-6His
Calculated MW	31670 Da

Additional Information
Target/Specificity	GFRA4
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	GFRA4
Function	Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:11116144). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (PubMed:11116144). May be important in C-cell development and, in the postnatal development of the adrenal medulla (PubMed:11116144).
Cellular Location	[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor [Isoform GFRalpha4c]: Secreted
Tissue Location	Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol