> 首页 > 产品 > 一抗 > 其他 > Anti-MMP-16 Reference Antibody (Abbvie patent anti-MMP-16)

Anti-MMP-16 Reference Antibody (Abbvie patent anti-MMP-16)

Anti-MMP-16 Reference Antibody (Abbvie patent anti-MMP-16) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-MMP-16 Reference Antibody (Abbvie patent anti-MMP-16) is 98.1%, determined by SEC-HPLC.
PLVX-puro-MMP-16-FL cell line were stained with Abbvie patent anti-MMP-16 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.432 nM.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P51512
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-CS-noK
Calculated MW	69521 Da

Additional Information
Target/Specificity	MMP-16
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	MMP16 (HGNC:7162)
Function	Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Cellular Location	[Isoform Long]: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells
Tissue Location	Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol