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Anti-JAG1 / CD339 Reference Antibody (Genentech patent anti-Jagged1)

Anti-JAG1 / CD339 Reference Antibody (Genentech patent anti-Jagged1) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-JAG1 / CD339 Reference Antibody (Genentech patent anti-Jagged1) is 98.5%, determined by SEC-HPLC.
Immobilized hu-Jagged1-his, It’s target at 2 µg/mL can bind bamlanivimab, EC50= 0.01259 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P78504
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	133799 Da

Additional Information
Target/Specificity	JAG1 / CD339
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	JAG1
Synonyms	JAGL1
Function	Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Cellular Location	Membrane; Single-pass type I membrane protein. Cell membrane
Tissue Location	Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells