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Anti-TNFRSF1A / TNFAR / CD120a Reference Antibody (GSK1995057)

Anti-TNFRSF1A / TNFAR / CD120a Reference Antibody (GSK1995057) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TNFRSF1A / TNFAR / CD120a Reference Antibody (GSK1995057) is 94.69%, determined by SEC-HPLC.
HuTNFR1-HEK293 cell line were stained with GSK1995057 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.137 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P19438
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-CS
Calculated MW	50495 Da

Additional Information
Target/Specificity	TNFRSF1A / TNFAR / CD120a
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	TNFRSF1A
Synonyms	TNFAR, TNFR1
Function	Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin- alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Cellular Location	Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing

Research Areas