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Anti-CCL11 Reference Antibody (bertilimumab)

Immobilized Human CD326 (His Tag, 2 µg/mL) can bind to Anti- Human CD326,（17-1A ） In Vivo Mab with an EC50 of 0.2912 µg/mL.
Anti- Human CD326,（17-1A ） In Vivo Mab on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti- Human CD326,（17-1A ） In Vivo Mab is 95%, determined by SEC-HPLC.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P51671
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP
Calculated MW	10732 Da

Additional Information
Target/Specificity	CCL11
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CCL11
Synonyms	SCYA11
Function	Chemokine that plays a central role in both allergic and non- allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed:8597956, PubMed:33846499). Exerts its effects primarily by binding to the CCR3 receptor (PubMed:8631813). Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway (PubMed:28279120).
Cellular Location	Secreted