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Anti-Netrin-1 Reference Antibody (NP137)

Anti-Netrin-1 Reference Antibody (NP137) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-Netrin-1 Reference Antibody (NP137) is 99.59%, determined by SEC-HPLC.
Immobilized hu-Netrin-1(O95631)-his, It’s target at 2 µg/mL can bind NP137, EC50= 0.006868 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O95631
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	67748 Da

Additional Information
Target/Specificity	Netrin-1
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	NTN1
Synonyms	NTN1L
Function	Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).
Cellular Location	Secreted. Cytoplasm. Note=Mainly secreted
Tissue Location	Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).