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Anti-TNFRSF1B / TNFR2 / CD120b Reference Antibody (HFB200301)

Anti-TNFRSF1B / TNFR2 / CD120b Reference Antibody (HFB200301) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TNFRSF1B / TNFR2 / CD120b Reference Antibody (HFB200301) is 99.8%, determined by SEC-HPLC.
TNFR2-HEK293 cell line were stained with HFB200301 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 94.2 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P20333
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-EM
Calculated MW	48291 Da

Additional Information
Target/Specificity	TNFRSF1B / TNFR2 / CD120b
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	TNFRSF1B
Synonyms	TNFBR, TNFR2
Function	Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity.
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Tumor necrosis factor-binding protein 2]: Secreted

Research Areas