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Anti-BCAM Reference Antibody (Genome and Co. patent anti-BCAM)

Anti-BCAM Reference Antibody (Genome and Co. patent anti-BCAM) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-BCAM Reference Antibody (Genome and Co. patent anti-BCAM) is 95.6%, determined by SEC-HPLC.
PLVX-puro-BCAM-FL cell line were stained with Genome and Co. patent anti-BCAM and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.252 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P50895
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP-Opti
Calculated MW	67405 Da

Additional Information
Target/Specificity	BCAM
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	BCAM
Synonyms	LU, MSK19
Function	Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls