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Anti-KRAS Reference Antibody (Genentech patent anti-KRAS)

Anti-KRAS Reference Antibody (Genentech patent anti-KRAS) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-KRAS Reference Antibody (Genentech patent anti-KRAS) is 98.7%, determined by SEC-HPLC.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P01116
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	21656 Da

Additional Information
Target/Specificity	KRAS
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	KRAS
Synonyms	KRAS2, RASK2
Function	Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22711838, PubMed:23698361). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300).
Cellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Endomembrane system. Cytoplasm
Tissue Location	Expressed throughout the epidermis, but weakly expressed in the stratum corneum and dermis (at protein level)