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Anti-ITGAD Reference Antibody (Lilly patent anti-ITGAD)

Anti-ITGAD Reference Antibody (Lilly patent anti-ITGAD) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ITGAD Reference Antibody (Lilly patent anti-ITGAD) is 100%, determined by SEC-HPLC.
PLVX-puro-ITGAD-FL cell line were stained with Lilly patent anti-ITGAD and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.4032 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q13349
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP-opti-FALA
Calculated MW	126758 Da

Additional Information
Target/Specificity	ITGAD
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ITGAD (HGNC:6146)
Function	Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (Probable).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue- specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages