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Anti-EGFR & HER3 Reference Antibody (Izalontamab)

Anti-EGFR & HER3 Reference Antibody (Izalontamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-EGFR & HER3 Reference Antibody (Izalontamab) is 99.43%, determined by SEC-HPLC.
Izalontamab bound to EGFR protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Izalontamab bound to huEGFR-his, and the EC50 was 0.019 nM.
Izalontamab bound to HER3 protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Izalontamab bound to huHER3-his, and the EC50 was 0.059 nM.
Izalontamab bound to EGFR-CHO-K cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Izalontamab bound to EGFR-CHO-K cells, and the EC50 was 0.937 nM.
Izalontamab bound to hu-HER3-FL-HEK293 cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Izalontamab bound to hu-HER3-FL-HEK293 cells, and the EC50 was 1.225 nM.
The detected molecular weight of Anti-EGFR & HER3 Reference Antibody (Izalontamab) is 197.21 kDa.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P00533 & P21860
Reactivity	Human
Clonality	Bispecific
Isotype	IgG-scFv

Additional Information
Target/Specificity	ERBB1 / EGFR / HER1,ERBB3 / HER3
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.