癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SARS Envelope Antibody
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Application 
| E |
|---|---|
| Primary Accession | P59637 |
| Other Accession | P59637, 30173401 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 8361 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SARS envelope antibody can be used for the detection of SARS envelope protein in ELISA. It will detect 10 ng of free peptide at 1 µg/mL. |
| Other Names | SARS Envelope Antibody: sM, 4, Envelope small membrane protein, E protein, Envelope small membrane protein |
|---|---|
| Target/Specificity | E; |
| Reconstitution & Storage | SARS Envelope antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SARS Envelope Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | E {ECO:0000255|HAMAP-Rule:MF_04204} |
|---|---|
| Synonyms | sM |
| Function | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction. |
| Cellular Location | Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:21450821, ECO:0000269|PubMed:24788150}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04204}. Note=Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307) The cytoplasmic tail functions as a Golgi complex-targeting signal {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:20861307, ECO:0000269|PubMed:21450821} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.
REFERENCES
Marra MA, Jones SJ, Astell CR, et al. The Genome sequence of the SARS-associated corona virus. Science 2003;300:1399-404.
Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-9.
Navas-Nartin SR and Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol. 2004;10:75-85.
Arbely E, Khattari Z, Brotons G, et al. A highly unusual palindromic transmembrane helical hairpin formed by SARS coronavirus E protein. J Mol. Biol. 2004;3414:769-79.
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