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EMX2 Antibody
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- 背景知识
Application 
| E, IHC-P |
|---|---|
| Primary Accession | Q04743 |
| Other Accession | Q04743, 19862512 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 28303 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | EMX2 antibody can be used for detection of EMX2 by immunohistochemistry at 5 µg/mL. |
| Gene ID | 2018 |
|---|---|
| Other Names | EMX2 Antibody: Homeobox protein EMX2, Empty spiracles homolog 2, empty spiracles homeobox 2 |
| Target/Specificity | EMX2; At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1. |
| Reconstitution & Storage | EMX2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | EMX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EMX2 |
|---|---|
| Function | Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combination with OTX1/2 to specify cell fates in the developing central nervous system. In the inner ear, it controls the distribution of GPR156 at hair cell boundaries, and regulates the organization of stereociliary bundles in opposite orientations across the line of polarity reversal (LPR). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q04744}. Cell projection, axon {ECO:0000250|UniProtKB:Q04744}. Note=Detected in axons within the olfactory mucosa and glomeruli in the olfactory bulb {ECO:0000250|UniProtKB:Q04744} |
| Tissue Location | Cerebral cortex. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10.
REFERENCES
Bishop KM, Garel S, Nakagawa Y, et al. EMX1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J. Comp. Neurol. 2003; 457:345-60.
Lichtneckert R, Nobs L, Reichert H. Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila. Development 2008; 135:2415-24.
Gulisano M, et al. EMX2 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse. Eur. J. Neurosci. 1996; 8:1037-50.
Nedelec S, Foucher I, Brunet I, et al. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc. Natl. Acad. Sci. USA 2004; 101:10815-20.
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