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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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Grik3 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q13003 |
| Other Accession | CAI19119, 56205347 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 104037 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 2899 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 3, GluK3, Excitatory amino acid receptor 5, EAA5, Glutamate receptor 7, GluR-7, GluR7, GRIK3, GLUR7 |
| Target/Specificity | GRIK3; |
| Reconstitution & Storage | Grik3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | Grik3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIK3 |
|---|---|
| Synonyms | GLUR7 |
| Function | Ionotropic glutamate receptor that functions as a cation- permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:7719709). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P42264}; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42264}; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Grik3 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
REFERENCES
Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
Puranam RS, Eubanks JH, Heinemann SF, et al. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Mol. Genet.1993; 19:581-8.
Pinheiro PS, Perrais D, Coussen F, et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA2007; 104:12181-6.
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