癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RIM2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| E, IHC-P |
|---|---|
| Primary Accession | Q9UQ26 |
| Other Accession | NP_001093587, 154354983 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 160403 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | RIM2 antibody can be used for detection of RIM2 by immunohistochemistry at 5 µg/mL. |
| Gene ID | 9699 |
|---|---|
| Other Names | Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3, RIMS2, KIAA0751, RAB3IP3, RIM2 |
| Target/Specificity | RIMS2; |
| Reconstitution & Storage | RIM2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | RIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RIMS2 |
|---|---|
| Synonyms | KIAA0751, RAB3IP3, RIM2 |
| Function | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane; Peripheral membrane protein |
| Tissue Location | Widely expressed (PubMed:32470375). Expressed in melanocytes (PubMed:23999003). In fetal tissues, predominantly expressed in the brain (PubMed:32470375). In the retina, expressed in the outer plexiform layer (at protein level) (PubMed:32470375). In the cerebellum, expressed in Purkinje cells (at protein level) (PubMed:32470375). In the pancreas, expressed in Langerhans islets (at protein level) (PubMed:32470375). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
REFERENCES
Wang Y, Sugita S, and Sudhof TC. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 2000; 275:20033-44.
Liang F, Zhang B, Tang J, et al. RIM3gamma is a postsynaptic protein in the rat central nervous system. J. Comp. Neurol. 2007; 503:501-10
Shoch S, Mittelstaedt T, Kaeser PS, et al. Redundant functions of RIM1α and RIM2α in Ca2+-triggered neurotransmitter release. EMBO J. 2006; 25:5852-63.
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