癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RGP1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q92546 |
| Other Accession | NP_001073965, 122937426 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 42455 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | RGP1 antibody can be used for detection of RGP1 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 9827 |
|---|---|
| Other Names | RAB6A-GEF complex partner protein 2, Retrograde Golgi transport protein RGP1 homolog, RGP1 (HGNC:21965), KIAA0258 |
| Target/Specificity | RGP1; |
| Reconstitution & Storage | RGP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | RGP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGP1 (HGNC:21965) |
|---|---|
| Synonyms | KIAA0258 |
| Function | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. |
| Cellular Location | Cytoplasm, cytosol. Membrane |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RGP1 Antibody: Retrograde golgi transport homolog 1 (RGP1) is the mammalian homolog to the yeast RGP1, a protein that forms a tight complex with RIC1. This complex binds Ypt6p and stimulates guanine nucleotide exchange. RGP1 is localized to the Golgi and is thought to be a potential Golgi recycling factor. Rgp1 yeast mutants exhibit defects in retrograde trafficking similar to those seen in yeast with mutations in other retrograde Golgi transport proteins. It is expected that RGP1 plays a similar role in mammalian cells to that seen in yeast.
REFERENCES
Siniossoglou S, Peak-Chew SY, and Pelham HRB. Ric1p and Rgp1 form a complex that catalyzes nucleotide exchange on Ypt6p. EMBO J.2000; 19:4885-94.
Panek HR, Conibear E, Bryan JD, et al. Identification of Rgp1, a novel Golgi recycling factor, as a protein required for efficient localization of yeast casein kinase 1 to the plasma membrane. J. Cell Sci.113:4545-55.
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