癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RGPD5 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q99666 |
| Other Accession | NP_005045, 83267877 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 198924 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | RGPD5 antibody can be used for detection of RGPD5 by Western blot at 1 µg/mL. |
| Gene ID | 729540;84220 |
|---|---|
| Other Names | RANBP2-like and GRIP domain-containing protein 5/6, Ran-binding protein 2-like 1/2, RanBP2-like 1/2, RanBP2L1, RanBP2L2, Sperm membrane protein BS-63, RGPD5, RANBP2L1, RGP5, RGP7, RGPD7 |
| Target/Specificity | RGPD5; |
| Reconstitution & Storage | RGPD5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | RGPD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RGPD5 |
|---|---|
| Synonyms | RANBP2L1, RGP5, RGP7, RGPD7 |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in testis.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RGPD5 Antibody: The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.
REFERENCES
Nothwang HG, Rensing C, Kubler M, et al. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on chromosome 2q11-q12. Genomics1998; 47:383-92.
Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.
Wang LF, Zhu HD, Miao SY, et al. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch. Androl.1999; 42:71-84.
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