癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MIPU1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q5HYK9 |
| Other Accession | NP_071386, 38524600 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 70161 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | MIPU1 antibody can be used for detection of MIPU1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 63934 |
|---|---|
| Other Names | Zinc finger protein 667, ZNF667 |
| Target/Specificity | ZNF667; |
| Reconstitution & Storage | MIPU1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MIPU1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF667 |
|---|---|
| Function | May be involved in transcriptional regulation. |
| Cellular Location | Nucleus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MIPU1 Antibody: Mipu1, also known as zinc finger protein 667 or ZNF667, encodes a nuclear-localized protein containing 14 carboxy-terminal zinc finger motifs and an amino-terminal KRAB domain. This protein is highly expressed in heart and brain and is upregulated in rat heart after a transient ischemia-reperfusion procedure. Overexpression experiments suggest that Mipu1 suppresses the transcriptional activities of AP-1 and SRE in the MAPK signaling pathway and thus may play a role in the pathogenesis of cardiac and vascular disease. At least four isoforms of MIPU1 are known to exist.
REFERENCES
Jiang L, Tang D, Wang K, et al. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Biochem. Biophys. Res. Commun.2007; 356:829-35.
Wang G, Zuo X, Jiang L, et al. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene. Braz. J. Biol. Res.2009; epub.
Yuan C, Zhang HL, Liu Y, et al. Cloning and characterization of a new gene Mipu1 up-regulated during myocardial ischemia-reperfusion. Prog. Biochem. Biophys.2004; 31:231-6.
Wang G, Zuo X, Yuan C, et al. Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway. Mol. Cell. Biochem.2009; 322:93-102.
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