癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZCRB1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TBF4 |
| Other Accession | NP_149105, 51243065 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 24592 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | ZCRB1 antibody can be used for detection of ZCRB1 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 85437 |
|---|---|
| Other Names | Zinc finger CCHC-type and RNA-binding motif-containing protein 1, U11/U12 small nuclear ribonucleoprotein 31 kDa protein, U11/U12 snRNP 31 kDa protein, U11/U12-31K, ZCRB1 |
| Target/Specificity | ZCRB1; |
| Reconstitution & Storage | ZCRB1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | ZCRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZCRB1 |
|---|---|
| Cellular Location | Nucleus, nucleoplasm |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ZCRB1 Antibody: ZCRB1 is a nuclear protein first identified in a differential display screen involving morphine-dependence-related genes. Its expression is increased following morphine treatment and has been observed to be elevated in HepG2 cells. ZCRB1 contains a CCHC-type zing finger RNA-binding motif and can interact with the DBA-binding domain of the stem cell regulator C/EBP transcription factors. ZCRB1 was identified as one of the protein components of U11/U12 snRNPs, which are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron, suggesting ZCRB1 may play a key role in U12-type splicing.
REFERENCES
Wang H, Gao MX, Li L, et al. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q2. Genomics2007; 89:59-69.
Trivedi AK, Bararia D, Christopeit M, et al. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene2007; 1789-801.
Will CL, Schneider C, Hossbach M, et al. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA2004; 10:929-41.
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