癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HAAO Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | P46952 |
| Other Accession | NP_036337, 188497625 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 32556 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | HAAO antibody can be used for detection of HAAO by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 23498 |
|---|---|
| Other Names | 3-hydroxyanthranilate 3, 4-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}, 1.13.11.6 {ECO:0000255|HAMAP-Rule:MF_03019}, 3-hydroxyanthranilate oxygenase {ECO:0000255|HAMAP-Rule:MF_03019}, 3-HAO {ECO:0000255|HAMAP-Rule:MF_03019}, 3-hydroxyanthranilic acid dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}, HAD {ECO:0000255|HAMAP-Rule:MF_03019}, HAAO {ECO:0000255|HAMAP-Rule:MF_03019} |
| Target/Specificity | HAAO; |
| Reconstitution & Storage | HAAO antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | HAAO Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HAAO {ECO:0000255|HAMAP-Rule:MF_03019, ECO:0000312|HGNC:HGNC:4796} |
|---|---|
| Function | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Cellular Location | Cytoplasm, cytosol. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
REFERENCES
Decker RH, Kang HH, Leach FR, et al. Purification and properties of 3-hydroxyanthranilic acid oxidase. J. Biol. Chem.1961; 236:3076-82.
Huang YW, Jansen RA, Fabbri E, et al. Identification of candidate epigenetic biomarkers for ovarian cancer detection. Oncol. Rep.2009; 22:853-61.
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