癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SYPL1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16563 |
| Other Accession | NP_006745, 5803185 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 28565 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SYPL1 antibody can be used for detection of SYPL1 by Western blot at 1 µg/mL. |
| Gene ID | 6856 |
|---|---|
| Other Names | Synaptophysin-like protein 1, Pantophysin, SYPL1, SYPL |
| Target/Specificity | SYPL1; This antibody will not recognize synaptophysin of SYPL2. Two isoforms of SYPL1 are known to exist; this antibody will only recognize the longer isoform. |
| Reconstitution & Storage | SYPL1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SYPL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYPL1 |
|---|---|
| Synonyms | SYPL |
| Cellular Location | Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SYPL1 Antibody: The synaptophysin-like protein 1, also known as pantophysin, is a homolog of the neuroendocrine-specific protein synaptophysin, with the highest level of homology across its four transmembrane domains. Unlike synaptophysin however, SYPL1 is ubiquitously expressed and found in small cytoplasmic transport vesicles regardless of their content. SYPL1 is thought to play a multifunctional role in vesicle biogenesis and transport and is a component of adipocyte transport vesicles, and thus may be involved in adipocyte secretion. SYPL1 also interacts with vesicle-associated membrane protein 2 (VAMP-2) in adipocytes and associates with GLUT4-containing vesicles.
REFERENCES
Haass NK, Kartenbeck MA, and Leube RE. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. J. Cell Biol.1996; 134:731-46.
Brooks CC, Scherer PE, Cleveland K, et al. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containin vesicles. J. Biol. Chem.2000; 275:2029-36.
Bradley RL, Cleveland KA, and Cheatham B. The adipocyte as a secretory organ: mechanism of vesicle transport and secretory pathways. Recent Prog. Horm. Res.2001; 56:329-58.
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