癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PGCC1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EK7 |
| Other Accession | Q96EK7, 74751843 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 103783 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | PGCC1 antibody can be used for detection of PGCC1 by Western blot at 0.5 - 1 µg/mL. |
| Gene ID | 84498 |
|---|---|
| Other Names | Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Constitutive coactivator of PPAR-gamma, Constitutive coactivator of PPARG, PPARG constitutive coactivator 1, PGCC1, Protein FAM120B, FAM120B, CCPG, KIAA1838 |
| Target/Specificity | FAM120B; This antibody will not cross-react with FAM120A. |
| Reconstitution & Storage | PGCC1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | PGCC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FAM120B |
|---|---|
| Synonyms | CCPG, KIAA1838 |
| Function | Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PGCC1 Antibody: The transcription factor peroxisome proliferator-activated receptor gamma (PPARg) plays essential roles in adipogenesis by regulating adipocyte-specific genes through association of various co-factors. One such co-factor, PGCC1 (also known as FAM120B), is widely expressed in adult tissues and throughout embryonic development. Overexpression of this protein in OP9 pre-adipocytes promoted their differentiation into adipocytes, and knockdown of PGCC1 expression through RNA interference blocked this process. PGCC1 is homologous to C9orf10 (also known as FAM120A) and has been mapped to chromosome Xp11.22. At least two isoforms of PGCC1 are known to exist.
REFERENCES
Berger J and Moller DE. The mechanisms of actions of PPARs. Annu. Rev. Med.2002; 53:409-35.
Li D, Kang Q, and Wang D-M. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARg), a novel coactivator of PPARg that promotes adipogenesis. Mol. Endocrin.2007; 21:2320-33.
Holden S and Raymond FL. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. Gene2003; 318:149-61.
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