癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MARVELD1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BSK0 |
| Other Accession | EAW49903, 119570288 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 18914 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | MARVELD1 antibody can be used for detection of MARVELD1 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 83742 |
|---|---|
| Other Names | MARVEL domain-containing protein 1, MARVELD1, MRVLDC1 |
| Target/Specificity | MARVELD1; |
| Reconstitution & Storage | MARVELD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MARVELD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARVELD1 |
|---|---|
| Synonyms | MRVLDC1 |
| Function | Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). |
| Tissue Location | Widely expressed in normal tissues. Down-regulated in multiple primary tumors. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MARVELD1 Antibody: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.
REFERENCES
Wang S, Li Y, Han F, et al. On of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. Cancer Lett.2009; 282:77-86.
Alves PM, Levy N, Stevenson BJ, et al. Identification of tumor-associated antigens by large scale analysis of genes expressed in human colorectal cancer. Cancer Immun.2008; 8:11.
Hatada I, Fukasawa M, and Kimura M. Genome-wide profiling of promoter methylation in human. Oncogene2006; 25:3059-64.
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