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PPAPDC2 Antibody
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- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8IY26 |
| Other Accession | NP_982278, 66773040 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 32194 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | PPAPDC2 antibody can be used for detection of PPAPDC2 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 403313 |
|---|---|
| Other Names | Presqualene diphosphate phosphatase, 3.1.3.-, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2, PPAPDC2 |
| Target/Specificity | PPAPDC2; |
| Reconstitution & Storage | PPAPDC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | PPAPDC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLPP6 (HGNC:23682) |
|---|---|
| Function | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine- 1-phosphate (PubMed:18930839, PubMed:20110354). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Nucleus inner membrane |
| Tissue Location | Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PPAPDC2 Antibody: PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
REFERENCES
Fukunaga K, Arita M, Takahashi M, et al. Identification and functional characterization of a presqualene diphosphate phosphatase. J. Biol. Chem.2006; 281:9490-7.
Miriyala S, Subramanian T, Panchatcharam M, et al. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J. Biol. Chem.2010 (epub).
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