癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAM212A Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EL1 |
| Other Accession | NP_976248, 42766424 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 31574 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | FAM212A antibody can be used for detection of FAM212A by Western blot at 1 - 2 µg/ml. |
| Gene ID | 389119 |
|---|---|
| Other Names | Protein FAM212A, FAM212A, C3orf54 |
| Target/Specificity | FAM212A; FAM212A antibody is human and mouse . At least two isoforms of FAM212A are known to exist; this antibody will recognize both isoforms. |
| Reconstitution & Storage | FAM212A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | FAM212A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | INKA1 (HGNC:32480) |
|---|---|
| Function | Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). |
| Cellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear (PubMed:26607847) Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives (1). FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics (1). In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly (2).
REFERENCES
Luo T, Xu Y, Hoffman TL, et al. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Dev. 2007; 134:1279-89.
Reid BS, Sargent TD, and Willams T. Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev. Dyn. 2010; 239:1188-96.
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