癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
REEP4 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H6H4 |
| Other Accession | EAW63714, 119584118 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 29395 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | REEP4 antibody can be used for detection of REEP4 by Western blot at 1 µg/mL. |
| Gene ID | 80346 |
|---|---|
| Other Names | Receptor expression-enhancing protein 4, REEP4, C8orf20 |
| Target/Specificity | REEP4; |
| Reconstitution & Storage | REEP4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | REEP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | REEP4 |
|---|---|
| Synonyms | C8orf20 |
| Function | Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in circumvallate papillae and testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
REEP4 Antibody: Mammalian odorant receptors require accessory proteins such as RTP1 and RTP2 for functional cell surface expression. Receptor expression-enhancing protein (REEP) family members are transmembrane proteins which interact with odorant receptor proteins and may enhance the odorant receptor responses to odorants. Recently studies have shown other chemosensory receptors such as bitter taste receptors are also influenced by RTP and REEP family members. In studies in Xenopus RNAi to reduce REEP4 levels, embryos showed a slightly kinked body axis and were paralyzed. Further analysis revealed downregulated levels of several neural and muscle markers, suggesting the REEP4 may play a role in the maintenance of both the nervous system and musculature.
REFERENCES
Saito H, Kubota M, Roberts RW, et al. RTP family members induce functional expression of mammalian odorant receptors. Cell2004; 119:679-91.
Behrens M, Bartelt J, Reichling et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J. Biol. Chem.2006; 281:20650-9.
Argasinska J, Rana AA, Gilchrist MJ, et al. Loss of REEP4 causes paralysis of the Xenopus embryo. Int. J. Dev. Biol.2009; 52:37-43.
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