癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM184A Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E, IHC-P |
|---|---|
| Primary Accession | Q6ZMB5 |
| Other Accession | NP_001091089, 148276981 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 45777 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TMEM184A antibody can be used for detection of TMEM184A by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 202915 |
|---|---|
| Other Names | Transmembrane protein 184A, TMEM184A |
| Target/Specificity | TMEM184A; |
| Reconstitution & Storage | TMEM184A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TMEM184A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM184A |
|---|---|
| Function | Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q4QQS1}; Multi-pass membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q4QQS1}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q1RMW2}; Multi-pass membrane protein. Early endosome membrane {ECO:0000250|UniProtKB:Q3UFJ6}; Multi-pass membrane protein. Endosome {ECO:0000250|UniProtKB:Q3UFJ6}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q3UFJ6} |
| Tissue Location | Expressed in vascular cells (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMEM184A Antibody: TMEM184A, a multi-pass transmembrane protein, belongs to the UPF0206 family. While the exact function of TMEM184A remains unclear, it is known to be expressed at high levels in the developing testis. TMEM184A may mediate sex-specific signaling events during Sertoli cell differentiation. The restricted expression of this gene in Sertoli cells suggests a role for the encoded protein in the development and/or continued function of that cell type. Ectopic expression of TMEM184A in female genital ridges resulted in failure of gonocytes to enter meiosis.
REFERENCES
Svingen T, Beverdam A, Bernard P, et al. Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction2007; 133:983-9.
Svingen T, Wilhelm D, Combes AN, et al. Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis. Dev Dyn.2009; 238:956-64.
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